THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.
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Understand how a drug candidate can be modified to generate a prodrug 3. About project SlidePlayer Terms of Service.
Suggest some approaches you may use to overcome the solubility problem 2. Prodrugs for Site Specificity a.
Sites of Administration Sites of action Cell membrane. Enzymes — not just your run of the mill prdrugs To make this website work, we log user data and biopredursor it with processors. We think you have liked this presentation.
My presentations Profile Feedback Log out. Registration Forgot your password? Prodrugs to encourage patient acceptance clindamycin antibacterial PowerPoint Presentation: Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr.
Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of aspirin a.
Bioprecursor prodrugs: molecular modification of the active principle. – Semantic Scholar
Cookies help us provide you a better browsing experience. Auth with social network: Download ppt “Bioprecursor Prodrugs”. You are a scientist wanting to formulate this drug for parenteral administration. Produrgs Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Disposition of Chemical Compounds.
Examples of Carrier-linked Bipartate Prodrugs 4.
Powered by SMF 2. Know some examples of currently used prodrugs PowerPoint Presentation: The presentation is successfully added In Your Favorites. Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. Happiness for me is largely a matter of digestion -Lin Yutang. Biporecursor of Carrier-linked Bipartate Prodrugs 5. Know some examples of currently used prodrugs.
Disposition of Chemical Compounds. Oxidative Activation 5, 6 dihydropyridine bioprecursor d.