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Dr. William Heberden, a London physician, described the first cases of Henoch- Schönlein purpura (HSP) in In describing HSP, Heberden wrote of a. Henoch-Schönlein purpura (HSP) affects the blood vessels and causes a spotty rash. It’s not usually serious, but can sometimes lead to kidney problems. Henoch–Schönlein purpura (HSP) is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin.

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Blood and urine tests are used to check the kidney function of people with HSP for at least 6 months after the main symptoms disappear.

Henoch-Schonlein purpura – Symptoms, diagnosis and treatment | BMJ Best Practice

Women with a history of HSP who become pregnant are at higher risk for high blood pressure and proteinuria during pregnancy. The platelet count may be raised, and distinguishes it from diseases where low platelets are the cause of the purpura, such as idiopathic thrombocytopenic purpura and thrombotic thrombocytopenic purpura.

If the kidneys are involved there will be blood, which can be visible macroscopic or only found on dipstick testing microscopic as well as protein in the urine. Most common vasculitis schonlfin childhood.

About Vasculitis

Pain and swelling can occur in the joints, usually in the knees and ankles and less frequently in the elbows and wrists. Never ever shake a baby.

In adults, kidney involvement progresses to end-stage kidney disease ESKD more often than in children. More than half also have proteinuria protein in the urinewhich in one eighth is severe enough to cause nephrotic syndrome generalised swelling due to low protein content of the blood. However, some adults can present with new HSP having never experienced it in their youth.


Henocu is HSP diagnosed? Content is regularly updated so please refer to www. In children, it usually resolves within several weeks and requires no treatment apart from symptom control but may relapse in a third of cases and cause irreversible kidney damage in about one in a hundred cases.

Henoch-Schönlein Purpura

From Wikipedia, the free encyclopedia. Most people with HSP make a full recovery. Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis. Hematuria and proteinuria are detected using urinalysis, which is testing of a urine sample. Blood may also appear in the stool, though severe bleeding is rare. Sufficient pressure, such as this, causes the rupture of inflamed blood vessels.

The NIDDK translates and disseminates research aadalah through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine hematuria and proteinuriabut this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease.

Treatment may be indicated on the basis of the appearance of the biopsy sample; hehoch treatments may be used, ranging from steroids by mouth to a combination of intravenous methylprednisolone steroidcyclophosphamide and dipyridamole followed by prednisone.

It is dangerous to give more than the recommended dose. Beta blockers, calcium channel blockers, and other blood pressure medications may also be needed.

Henoch–Schönlein purpura – Wikipedia

However, an outbreak can occur on the abdomen, chest, or as in the case with this woman, on the upper extremities. Clinical and Experimental Dermatolology. If the skin, bowel or kidneys are affected then a biopsy may show immunoglobulin A IgA antibodies present in the tissue; this is a definitive test and a positive biopsy helps confirm the diagnosis; however, a negative biopsy does not rule out the diagnosis.


Swelling around the ankle and foot. In adults, HSP can lead to chronic kidney disease CKD and kidney failure, described as end-stage renal disease when treated with blood-filtering treatments called dialysis or a kidney transplant.

Researchers also use clinical trials to look at other aspects of care, such as improving the quality of life for people with chronic illnesses. This page last reviewed 10 December Return to your doctor or the hospital if your child has one or more of the following or if you are worried for any other reason:.

This may start out looking like red spots, bumps or raised skin welts which can be itchy. The test can confirm diagnosis and be used to determine the extent of kidney involvement, which will help guide treatment decisions. Hearing, vision and newborn screening. Rash of palpable purpura is present in all cases. Venepuncture and phlebotomy animated demonstration. Important You can get HSP more than once. Check a few times to see if you can still see the spots through the glass.